Ang II binding to its AT1R is a key mediator of myocardial and renal fibrosis ‐at least in part‐ by upregulating the expression of TGF‐b (Sun et al., 1998) and/or the TGF‐b receptor known as endoglin (Chen et al., 2004). This evidence concerns the gene TGFB1 and renal fibrosis.