However, Ang II activates NF‐kB after binding to AT1 and AT2 receptors; accordingly, in an unilateral ureteral obstruction model in mice, treatment with AT1 or AT2 antagonists only partly reduced NF‐kB activation, indicating that dual AT1 and AT2 blockade is needed to thoroughly inhibit inflammation in this model (Esteban et al., 2004). This evidence concerns the gene AGTR1 and Ureteral obstruction.