PIK3CG and Insulin resistance: Also, in patients with type 2 diabetic kidney disease, losartan reduced insulin resistance by attenuating oxidative stress (as assessed by determination of circulating 8‐hydroxy‐2′‐deoxyguanosine and nitrotyrosine levels) and improving insulin signaling transduction in 3T3‐L1 adipocytes through modulation of PI3K pathway, that is, by stimulating the protein expressions of phosphorylated insulin receptor, PI3K, and insulin receptor substrate 1 (Pan et al., 2015).