Having established that SNORA28 activates the LIFR/JAK1/STAT3 pathway to enhance CRC cell proliferation and radioresistance in vitro, we established mouse xenograft models of HT29/LV‐SNORA28 and HT29/LV‐NC to analyze its effect on CRC growth and radiosensitivity in vivo and elucidate its modulatory effect on the LIFR/JAK1/STAT3 pathway. The gene discussed is STAT3; the disease is colorectal carcinoma.