LIFR and colon adenocarcinoma: Previous reports demonstrated that the CpG islands in the LIFR promoter region of CRC cells are methylated.[27] Based on this, we used the UALCAN database for further analysis and found LIFR hypermethylation in colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) tissues in comparison with normal tissues (Figure 5A).