MIF and neoplasm: Orthosteric MIF inhibitors have been reported to inhibit tumor cell proliferation,[41, 64, 65] and neutrophil recruitment[66, 67] ′′MN123 is an allosteric MIF tautomerase that has yet to be investigated for interfering with the binding of MIF and its extracellular receptors.′′ Moreover, future in vivo validation is indispensable to further support the proposed model and move this therapeutic strategy from bench to bedside.