CVD patients of the positive group in T2DM showed significantly increased the levels of LDL‐C (p = 0.029), ApoB (p = 0.013), Lp‐PLA2 (p < 0.001), on the contrary, the levels of HDL‐C (p = 0.011) and CTRP‐3 (p < 0.001) and the proportion of antihypertensive therapy (p = 0.049) and lipid‐lowering therapy (p = 0.026), were significant lower in positive group compared with negative group (Table 1). This evidence concerns the gene C1QTNF3 and type 2 diabetes mellitus.