In conclusion, this study confirmed that the serum Lp‐PLA2 activity and levels of CTRP3 were abnormally expressed in CVD patients of T2DM, the measurement of Lp‐PLA2 and CTRP‐3 could improve the diagnostic efficacy for the detection of patients prone for CVD in T2DM. This evidence concerns the gene C1QTNF3 and type 2 diabetes mellitus.