In addition, this study aimed to compare the differences in Lp‐PLA2 and CTRP3 levels between patients with or without CVD in T2DM, to identify the potential CVD population at an early stage, thus achieving early intervention and improved disease outcomes, no further subgroup analysis was performed in CVD patients (distinguishing between cardiovascular death, acute coronary syndrome, and, coronary stent implantation), this study will be focused on in future research. This evidence concerns the gene C1QTNF3 and type 2 diabetes mellitus.