In addition, as indicated by the result of the ROC curve analysis, Lp‐PLA2 can accurately predict the occurrence of CVD in T2DM (AUC = 0.81 [95% CI: 0.77–0.85], p < 0.001); CTRP‐3 can be a strong predictor of CVD in T2DM (AUC = 0.91 [95% CI: 0.89–0.93], p < 0.001); the joint detection and prediction ability of the two was improved greatly (AUC = 0.94 [95% CI: 0.93–0.96], p < 0.001). This evidence concerns the gene PLA2G7 and type 2 diabetes mellitus.