In conclusion, this study confirmed that the serum Lp‐PLA2 activity and levels of CTRP3 were abnormally expressed in CVD patients of T2DM, the measurement of Lp‐PLA2 and CTRP‐3 could improve the diagnostic efficacy for the detection of patients prone for CVD in T2DM. Here, PLA2G7 is linked to type 2 diabetes mellitus.