To understand HIV interactions with ASDCs and bona-fide pDCs (depleted of CD123+ ASDCs), we examined the gene and surface expression of: i) lectin binding receptors that mediate endocytic uptake including those known to bind HIV: CD169/Siglec-1, CD209/DC-SIGN, CD206/MR and CD207/langerin; ii) the HIV entry receptors CD4, CCR5, and CXCR4 leading to productive infection; and iii) the myeloid cell retroviral restriction nuclear dNTPase SAMHD1. The gene discussed is CXCR4; the disease is infection.