pDCs have been historically associated with antiviral responses mediated by their: i) production of IFN-I α and β and subsequent IFN stimulated gene (ISG) expression; ii) production of chemokines and cytokines that recruit the primary HIV target CD4 T cells to sites of infection [1,3]; and iii) antigen presentation and priming of T cells. The gene discussed is CD4; the disease is infection.