Of the 24 genes that overlapped among the 3 lists (Fig 5A), we found that 8 genes (ABCC3, BMP7, TM4SF1, GPNMB, COBLL1, FRY, BCAT1, ENHO) were positively correlated with GLI2 expression in ESCC tissues (Fig 6A). This evidence concerns the gene FRY and esophageal squamous cell carcinoma.