Of the 24 genes that overlapped among the 3 lists (Fig 5A), we found that 8 genes (ABCC3, BMP7, TM4SF1, GPNMB, COBLL1, FRY, BCAT1, ENHO) were positively correlated with GLI2 expression in ESCC tissues (Fig 6A). The gene discussed is GPNMB; the disease is esophageal squamous cell carcinoma.