Brother of the regulator of imprinted sites (BORIS) [56], acrosin binding protein (ACRBP), synaptonemal complex protein 1 (SYCP1) [57, 58], and transmembrane protein 31 (TMEM31) [59] cancer/testis antigens have utilized for in silico peptide vaccine design due to their high expression in various tumors. The gene discussed is TMEM31; the disease is cancer.