PNPLA2 and metabolic dysfunction-associated steatohepatitis: This process inhibits the transcription of Cd36 and Ccl2, thereby suppressing NASH development.[56] Additionally, JMJD3 epigenetically upregulates the genes involved in the hepatic autophagy network, including Tfeb, Atg7, Atgl, and Fgf21, through histone H3K27me3 demethylation, leading to autophagy‐mediated lipid degradation.[57] While the effects of histone modifications on the intestinal barrier or hepatic steatosis involve multiple pathways, there has been no study to date that has explored the relationship between NSD2, H3K36me2, intestinal barrier integrity, and NASH.