Analogously, our current findings in OTSCC align with previous studies indicating a positive correlation between the expression of PLA2G2D and immune infiltration, as well as a better prognosis observed in HNSCC, breast cancer, and cervical squamous cell carcinoma,66, 67, 68 which aligns with the outcomes we have currently observed in OTSCC. Here, PLA2G2D is linked to head and neck squamous cell carcinoma.