Analogously, our current findings in OTSCC align with previous studies indicating a positive correlation between the expression of PLA2G2D and immune infiltration, as well as a better prognosis observed in HNSCC, breast cancer, and cervical squamous cell carcinoma,66, 67, 68 which aligns with the outcomes we have currently observed in OTSCC. The gene discussed is PLA2G2D; the disease is breast cancer.