AuNH‐2‐Ab confers dual‐targeting capabilities (i.e., anti‐PD‐L1 and magnetic targeting), thereby addressing the challenges associated with the insufficient and non‐specific accumulation of CI.[13] Through systematic tailoring of the dual targeting, photo‐responsive, thermosensitive, and immuno‐modulatory properties, AuNH‐2‐Ab effectively suppressed the growth of primary orthotropic hepatocellular carcinoma, elevated ICD levels, reversed TIME by alleviating the PD‐L1‐expressing TAMs, and consequently inhibited metastases. This evidence concerns the gene CD274 and hepatocellular carcinoma.