Colony formation assay and CCK‐8 assay showed that SERPINC1 promotes malignant proliferation of CRC cells, trans well assay showed that SERPINC1 promotes distant migratory behaviour of CRC cells and protein blotting assay showed that SERPINC1 may promote migration by promoting the TGF‐β1‐mediated EMT of CRC cells. Here, SERPINC1 is linked to colorectal carcinoma.