HTT and Huntington disease: As of now the emulation of HD‐associated phenotypes is mostly restricted to 2D applications.[6] Employing a membrane‐based microfluidic neurovascular model, Vatine et al.,[20] however, demonstrated a significant increase in barrier permeability upon comparing microvascular endothelial cells derived from three healthy patients to those derived from an HD patient carrying a 71 CAG repeat in the huntingtin (HTT) gene.