In addition, we clarified by further mechanistic experiments that NAT10 might lead to PCa cell growth and metastasis by catalyzing the ac4C acetylation of downstream high mobility group AT‐hook 1 (HMGA1) and keratin 8 (KRT8) mRNAs and subsequently stabilizing their mRNAs, leading to cell cycle progression and epithelial‐mesenchymal transition (EMT). Here, NAT10 is linked to posterior cortical atrophy.