Secondary analyses on pLOF variants in TTN cardiac isoforms (N2BA and N2B) and constitutively expressed cardiac exons found an even greater OR for AF (OR, 2.17; 95% CI, 1.93-2.43; P = 2.07 × 10−40 and OR, 3.85; 95% CI, 3.25-4.55; P = 1.09 × 10−55). The gene discussed is TTN; the disease is atrial fibrillation.