Other molecules, such as anti-cytotoxic T-lymphocyte associated antigen-4 (CTLA-4), T cell immunoreceptor with Ig and ITIM domains (TIGIT), T cell immunoglobulin mucin receptor 3 (TIM3), and lymphocyte activation gene 3 protein (LAG-3), are also overexpressed in various immune cells and act as inhibitory immune checkpoint modulators in GC (Table 4) [130, 183]. The gene discussed is TIGIT; the disease is gastric cancer.