A careful comparison of the data revealed significant upregulation of lncRNA SPACA6P-AS in multiple cancers, including bladder cancer (Ascione et al. 2023), BC (Nolan et al. 2023), head and neck squamous cell carcinoma (Johnson et al. 2020), and pancreatic cancer (Sherman and Beatty 2023), with a particularly notable increase in BC. Here, SPACA6 is linked to head and neck squamous cell carcinoma.