As a result of the GSEA analysis, the high LOXL2 expression group showed altered cancer-associated (Cell Cycle, TP53 Regulation), TME-associated (Collagen Degradation) and cellular senescence-associated (DNA Repair, Telomere Maintenance, Metabolic pathway) pathways in PAAD, LIHC, LUAD, and UVM (Fig. 5C). This evidence concerns the gene LOXL2 and cancer.