KMT2D and cancer: Furthermore, we evaluated the differences in gene alteration frequencies of tumors with higher expression of LOXL2, among the forementioned four types of tumors (UCEC, SKCM, COAD, and ESCA), APOB, USH2A, VPS13B, and KMT2D had the highest alteration frequency in the above cancer types (Fig. 3C).