No difference could be determined in the total frequency of extra-islet cells positive either for insulin or glucagon in donors with or without T1D (64 cells/mm2 in the T1D group, range 17–173 cells/mm2, and 31 cells/mm2 in the control group, range 13–151 cells/mm2, p = 0.11). The gene discussed is GCG; the disease is type 1 diabetes mellitus.