5 Perakakis Perakakis N N Farr Farr OM OM Mantzoros Mantzoros CS CS Leptin in Leanness and Obesity: JACC State-of-the-Art Review Leptin in Leanness and Obesity: JACC State-of-the-Art Review J Am Coll Cardiol J Am Coll Cardiol 2021 2021 77 77 6 6 745 745 760 760 10.1016/j.jacc.2020.11.069 10.1016/j.jacc.2020.11.069 33573745 33573745. This evidence concerns the gene LEP and obesity disorder.