Similar results occurred in irradiated enamel treated with commercial saliva BioXtra, except the lack of effect on CFU counting.21 Commercial saliva BioXtra is clinically applied as artificial saliva to relieve symptoms of dry mouth caused by radiotherapy.11It has lysozyme, lactoferrin, and lactoperoxidase, which are antimicrobial proteins.22 It contains MFP (1500 ppm F-); making artificial saliva able to reduce demineralization and increase remineralization. This evidence concerns the gene LPO and xerostomia.