TLR4 and infection: Investigation of the Cav-1 regulatory pathway of Cav-1 revealed a significant elevation in the TLR4 and MyD88 signaling pathways in the brains of mice infected with A. cantonensis on days 10 and 15 after infection (Figure 6), which is consistent in agreement with the observed increase in the Cav-1 and p-Cav-1 proteins during the same time frame.