Previous mice studies show that Fak deletion suppresses mammary tumorigenesis (Pylayeva et al., 2009; Luo et al., 2009), mutant Apc-induced intestinal tumorigenesis (Ashton et al., 2010), skin tumor formation (McLean et al., 2004), and hepatocarcinogenesis (Shang et al., 2015). The gene discussed is PTK2; the disease is skin neoplasm.