Patients with severe periodontitis exhibit significant increases in the expression of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), nod-like receptor protein 3 (NLRP3), and their absence in melanoma 2 (AIM2) inflammasomes in the gingival tissues [5,6]. The gene discussed is IL1B; the disease is periodontitis.