S10 effectively inhibited the secretions of IL-1β and TNF-α in an in vitro inflammatory model of infection induced by P. gingivalis (Figure 1A) and demonstrates that S10 effectively suppresses the P. gingivalis infection-induced secretions of the pro-inflammatory cytokines IL-1β and TNF-α by THP-1 macrophages (Figure 2A). This evidence concerns the gene TNF and infection.