Mice that received injections of PD-L1 Pep-1 and PD-L1 Pep-2 showed decreased tumour growth and an elevated CD8+/FoxP3+ ratio; however, when peptides and doxorubicin were delivered together via liposomes, the tumour was totally eradicated and the percentage of CD8+ T cells increased dramatically [167]. This evidence concerns the gene CD8A and neoplasm.