In conclusion, the logistic regression model established based on the four mRNAs and the two lncRNAs could effectively distinguish whether the sample type is ARVC or not, and XIST, LINC00173, FBN1, COL1A1, COL5A1, and BGN were potential targets for ARVC study. The gene discussed is COL5A1; the disease is arrhythmogenic right ventricular cardiomyopathy.