In conclusion, the logistic regression model established based on the four mRNAs and the two lncRNAs could effectively distinguish whether the sample type is ARVC or not, and XIST, LINC00173, FBN1, COL1A1, COL5A1, and BGN were potential targets for ARVC study. Here, COL1A1 is linked to arrhythmogenic right ventricular cardiomyopathy.