As shown in Figure 3H, I, pretreatment with 50 mg/kg and 100 mg/kg of ISE significantly reduced vWF expression in the pulmonary vascular endothelium of CLP-induced sepsis mice (vehicle + CLP group, 0.30 ± 0.03% vs. 50 mg/kg + ISE CLP, 0.18 ± 0.02%, ### p < 0.001; vs. 100 mg/kg ISE + CLP, 0.06 ± 0.01%, ### p < 0.001). This evidence concerns the gene VWF and Sepsis.