vWF and vWF-mediated signaling pathways contribute to coagulation, platelet activation, adhesion, and endothelial activation, making them attractive therapeutic targets for various thrombotic and infectious diseases, including stroke, thrombotic thrombocytopenic purpura, sepsis, and COVID-19 [22,23,24]. This evidence concerns the gene VWF and thrombotic thrombocytopenic purpura.