ANGPT1 and Sepsis: For instance, heparin (which protects against glycocalyx degradation), the Tie2 receptor agonist vasculotide (an angiopoietin-1 mimetic), and inhibitors of VE-cadherin internalization (via inhibition of the GTP-binding protein ARF6) are all promising therapies for reconstituting EC integrity during sepsis [3,21].