These data suggest the contribution of DD-9 against the proliferation of liver and cervical cancer cells mediated through GSK3-β activation, and enhancement of protein degradation, i.e., β-catenin, LEF1, p-GSK3-β, cyclinD1, and c-Myc of Wnt/β-catenin signaling cascade, as well as reduction of the nuclear accumulation of β-catenin. This evidence concerns the gene CCND1 and cervical carcinoma.