Taken together, DD-9, a bioactive compound obtained from chemical epigenetic manipulation of mangrove endophytic fungus Phomopsis asparagi DHS-48, may suppress proliferation and induce apoptosis of liver and cervical cancer cells, possibly at least in part via GSK-3β-mediated crosstalk with the Wnt/β-catenin signaling axis, providing insights into the mechanism for the potency of DD-9 on HCC and CC and laying a theoretical basis for this agent as a potential antitumor product. This evidence concerns the gene GSK3B and cervical carcinoma.