In addition, splenic gene expressions of the cytokines and nuclear factor kappa light chain enhancer of activated B cells (NF-κB) were downregulated in the CPA control group compared with the normal control; however, they were upregulated in the EAP, BS, PDS, and UDS groups compared with the CPA control (p < 0.01, Figure 5). The gene discussed is NFKB1; the disease is congenital primary aphakia.