Yan et al., in a rat HFD-induced MASLD model, found that the intragastric treatment of 50 mg/kg CGA significantly suppressed HFD-induced C-Jun N-terminal kinase 1 (JNK-1) level and resulted in ameliorated insulin resistance and autophagy [14], perceived as major factors in MASLD pathogenesis [42]. Here, MAPK8 is linked to Insulin resistance.