For instance, Silphium perfoliatum L. extract, rich in CGA, regulates the AMPK/FXR/SREPB-1c/PPAR-γ signaling pathway [93], Mailuoning Oral Liquid increased the expression of PPAR gamma coactivator-1α (PGC-1α) and restored the decreased expression of nuclear PPARα [94], yet natural dietary supplement Kèpar® shows not only beneficial effects in MASLD but also in atherosclerosis [95]. This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.