In vitro studies have shown that the overexpression of NNMT in the SH-SY5Y human neuroblastoma cell line confers various cytoprotective effects, such as increased complex I activity and ATP synthesis and resistance to mitotoxins linked to PD, including rotenone, 1-methyl-4-phenylpyridinium ion, and 6-hydroxydopamine [134,214]. The gene discussed is NNMT; the disease is neuroblastoma.