CBLN1 and Other metabolic disease: These differential metabolites and lipids, including n-acetylglutamic acid, citric acid, UA, 3-methyl pyruvic acid, l-phenylalanine, PE(16:0e/22:4), Cer(d16:0/16:0), DG (36:2e), Cer(d18:1/16:0), and DG(18:2/20:4) may be closely linked to HO and other metabolic disorders.