ACLY and cancer: Normal cells mainly take up and acquire lipids through exogenous sources, whereas cancer cells are more dependent on DNL to maintain lipid homeostasis to satisfy their own proliferation and growth needs, and this process is accompanied by a high expression of sterol regulatory element-binding protein 1c (SREBP1c), fatty acid synthase (FASN), ATP-citrate lyase (ACLY), and stearoyl-CoA desaturase 1 (SCD1) [106,107].