Since FXR and GBPAR1 are targeted by bile acids that are subject to modifications by the gut microbiota, it is tempting to speculate that dysbiosis in MASLD is associated with reduced intrahepatic H2S release that may contribute to sinusoidal vasoconstriction and increased intrahepatic vascular resistance. Here, NR1H4 is linked to metabolic dysfunction-associated steatotic liver disease.