BRD2 and diabetes mellitus: Therefore, the observed changes in serum taurine, including the decrease from triacetin treatment or the increase from 2% taurine supplement in the STZ-induced diabetes model, might have limited influence on the availability of intracellular taurine for the enzymatic performance in NAT synthesis, which may further explain the lack of increase in urinary NAT after the joint treatment of STZ and taurine (Figure 3D).