According to a previous study, the alleviation of insulin resistance (hyperglycemia and hyperinsulinemia) by dietary cholest-5-en-3-one is attributable to a decrease in the production of inflammatory cytokines, such as Ccl2 (MCP-1) and Il6 (IL-6), in the adipose tissues [16]. The gene discussed is CCL2; the disease is hyperinsulinism.