IDH1 and cancer: For example, cancer cells harboring mutant IDH are known to overproduce D-2-hydroxyglutarate (D-2HG), which has been shown, through the isotope-tracing of [U-13C6]glucose and [U-13C3]lactate, to modulate glycolysis in CD8+ T cells by inhibiting lactate dehydrogenase (LDH) [152].