CCN2 and pulmonary fibrosis: Following the observation of increased LPAR1/3 expression in mice exposed to 16 Gray radiation, the administration of VPC12249 effectively inhibited both the decline in survival and the progression of pulmonary fibrosis while also reducing the levels of pro-fibrotic cytokines such as transforming growth factor beta (TGFβ) and connective tissue growth factor (CTGF) [102].