GZMB and melanoma: Orlistat not only reduces the number of regulatory T cells (Tregs) and decreases the incidence of spontaneous B16-F10 melanoma metastasis but it also enhances the populations of CD80/CD86 and IL-12-positive dendritic cells, granzyme B/NKG2D-positive NK cells, and perforin/granzyme-B-positive CD8 T lymphocytes in primary tumors [80].