The first report to implicate Card9 in host resistance following high dose infection with C. neoformans B3501 identified early and transient reductions in the recruitment of interferon gamma-producing NK and memory phenotype T cells to the lung; however, the origin, specificity, and function of the latter cell subset was not defined and extrapulmonary fungal dissemination or survival differences were not reported [18]. The gene discussed is CARD9; the disease is infection.