CARD9 and infection: Thus, to gain further insight into the role of Card9 during the pathogenesis of cryptococcal pneumonia we challenged wild-type and Card9-mutant mice on the Balb/c background with a moderately virulent serotype D strain of C. neoformans (52D) using well-established experimental conditions and analyzed host resistance and immune responses at serial time points up to day 28 post-infection.