Detection of fungal infection by several host CLRs including Dectin-1, -2, -3 and Mincle triggers the recruitment and activation of spleen tyrosine kinase (Syk) that leads to the formation of a caspase recruitment domain-containing protein 9 (Card9)–B-cell lymphoma 10 (Bcl10)–mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (Malt1) scaffold complex [38]. Here, CLEC4E is linked to fungal infectious disease.