Sumitro et al.’s cross-sectional study [28] identified NLR as a viable, cost-effective alternative marker for neonatal sepsis in developing countries, showcasing a median NLR value of 3.63 in neonates with sepsis and establishing an NLR cut-off of ≥2.12 as significantly associated with positive blood culture results (relative risk = 1.867, p = 0.011), especially when combined with a CRP level of ≥2.70 mg/dL. The gene discussed is CRP; the disease is Neonatal sepsis.