Clinical trials clearly have established that G-CSF treatment (2–5 μg/kg/d) increases the neutrophil oscillations’ amplitude, shortens the neutropenia duration, and changes the cycle length from 21 to about 14 days, while patients have reported a reduction in recurrent fevers, mouth ulcers, and all other disease manifestations [10,11]. Here, CSF3 is linked to Decreased total neutrophil count.