Targeted next generation sequencing (NGS) revealed a NPM1 c.863_864insTCTG (W288fs) mutation at a variant allele frequency of 17.7% as well as a DNMT3A c.2645G>A (R882H) mutation at a variant allele frequency of 24.8%, two pathogenic aberrations that are highly associated with AML. The gene discussed is NPM1; the disease is acute myeloid leukemia.