A study from the European T-Cell Lymphoma Study Group identified a set of three genes (TNFRSF8, BATF3, and TMOD1) whose co-expression could potentially distinguish ALK-negative ALCL from PTCL-NOS, with an overall accuracy of approximately 97% in unrelated groups of patients [21]. The gene discussed is TNFRSF8; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.