Case 1 presented in this report would have been diagnosed as ALK-negative ALCL if an EBER stain had not been performed, underscoring the importance of including EBV staining, as well as a blood EBV titer test, in the diagnostic workup for cases suspected to be ALCL that exhibit a cytotoxic phenotype with CD8 expression and uniform CD30 expression. The gene discussed is TNFRSF8; the disease is anaplastic large cell lymphoma.