Before the inclusion of nodal EBV+ mature T-cell lymphoma as a variant of PTCL-NOS in the revised 4th edition WHO classification (WHO4RE) published in 2017, the classification of EBV+ mature T-cell lymphoma with strong uniform CD30 expression in tumor cells had been a topic of controversy, in part because the 4th edition WHO classification published in 2008 stated that in ALCL, ALK-negative is consistently negative for EBV. This evidence concerns the gene ALK and mature T-cell and NK-cell non-Hodgkin lymphoma.