Before the inclusion of nodal EBV+ mature T-cell lymphoma as a variant of PTCL-NOS in the revised 4th edition WHO classification (WHO4RE) published in 2017, the classification of EBV+ mature T-cell lymphoma with strong uniform CD30 expression in tumor cells had been a topic of controversy, in part because the 4th edition WHO classification published in 2008 stated that in ALCL, ALK-negative is consistently negative for EBV. The gene discussed is TNFRSF8; the disease is anaplastic large cell lymphoma.