To validate whether the expression of miRNAs obtained from the bioinformatics analysis increase with the presence of HPV, we analyzed the expression of common miRNAs in the three databases for each transcript PHD2, VHL, CUL2, and ELOC with the highest confidence parameters (Table 1) from the GSE158659 dataset of HPV-positive (SCC-154, SCC-090, SCC-047, SiHa, Ca Ski, C-4 I, HeLa, SW756) and HPV-negative (UPCI-017, UPCI-068, SCC-4, SCC-1, HT-3, C-33A) CSCC and HNSCC cell lines. Here, CUL2 is linked to head and neck squamous cell carcinoma.