ARNT and cancer: In this regard, the consequences of HIF-1α stability in cancer due to the effect of HPV 16 oncoproteins E6 and E7 involves the formation of active HIF-1 consisting of HIF-1α and HIF-1β, which is known to be an essential metabolic regulator that allows cancer cells to adapt to oxygen deprivation by enabling the transcription of 81 genes related to metabolic reprogramming [106].