In contrast, E7 increases the stability and expression of HIF-1α under hypoxia conditions [28,29] by inhibiting the expression of the hepatic kinase B1 (LKB1) tumor suppressor responsible for repressing HIF-1α expression [30] and by inhibiting Ras-related associated with diabetes (RRAD), which increases the levels of the p65 subunit of NF-kB, the transcription factor that promotes HIF-1α expression [31]. This evidence concerns the gene HIF1A and neoplasm.