HIF1A and colorectal carcinoma: To determine the possible effect of E6 and E7 oncoproteins on HIF1-α overexpression in CC, HNSC, and CRC where HPV 16 is a preponderant risk factor for its development, an interactome analysis was performed in the Bio GRID 4.4 database between the E6-E7-HIF1-α axis by integrating the interactomes in Cytoscape 3.8.2 to search for common nodes between in E6, E7, and HIF1-α.