RB1 and cancer: The oncogenic potential of HPV 16 is related to the production of E6 and E7 oncoproteins, which alter several processes related to cell transformation [72,73], including metabolic reprogramming, through degradation of p53 and retinoblastoma (pRb) and increased expression of c-Myc and HIF-1α, proteins that regulate cell metabolism in cancer [27].