These AD symptoms can worsen the inflammatory response in the skin by over-secreting chemokines (macrophage-derived chemokine (MDC), thymus- and activation-regulated chemokine (TARC)) and inflammatory cytokines (thymic stromal lymphopoietin (TSLP), IL-4, IL-25, and IL-33) in keratinocytes [12]. This evidence concerns the gene IL4 and Alzheimer disease.