FUS and amyotrophic lateral sclerosis: Other prominent genes linked to ALS pathology include C9orf72 (found in 39% of fALS cases and 7% of sALS cases), TDP-43 (present in 4.2% of fALS cases and 0.8% of sALS cases), and FUS (detected in 2.8% of fALS cases and less than 1% of sALS cases) Presently, only two medications, namely riluzole and edaravone (the latter not universally approved), are available for potential therapeutic interventions.