COL3A1 and metabolic dysfunction-associated steatohepatitis: In addition, the transcript levels of liver fibrosis-related genes such as collagen type I alpha 1 chain (Col1a1) and collagen type III alpha 1 chain (Col3a1) were significantly downregulated by YC-1102, indicating that YC-1102 could inhibit NASH-induced liver fibrosis [Figure 4B].