In addition, the transcript levels of liver fibrosis-related genes such as collagen type I alpha 1 chain (Col1a1) and collagen type III alpha 1 chain (Col3a1) were significantly downregulated by YC-1102, indicating that YC-1102 could inhibit NASH-induced liver fibrosis [Figure 4B]. The gene discussed is COL3A1; the disease is Hepatic fibrosis.