Regarding the oxidative stress associated with the autoimmune response in MS, curcumin enhances the antioxidant defense, acting as a scavenger of free radicals and increasing the activity of endogenous antioxidant enzymes, such as SOD and catalase, through the regulation of the KEAP1-Nrf2 pathway [60]. The gene discussed is NFE2L2; the disease is myeloid sarcoma.