In a similar context, the involvement of Hh signalling may be related to both the pathophysiology of schizophrenia (such as changes in myelin homeostasis, axonal development, and neural plasticity in general), mechanisms of action of antipsychotic drugs (such as the induction of NMDA receptors, the shift of dopamine towards D1 receptors, and Dhcr7 modifications), and potential pharmacological side effects. Here, DHCR7 is linked to schizophrenia.