However, even though VGF is a neuropeptide precursor induced by BDNF and elevated levels of VGF have been detected in the prefrontal cortex and cerebrospinal fluid of individuals with schizophrenia, a study conducted on VGF-overexpressing mice exhibiting schizophrenia-like behaviours revealed no alterations in the Hh pathway [27]. The gene discussed is BDNF; the disease is schizophrenia.