The development of studies investigating the potential interplay between epigenetics, inflammation, and AHA is crucial to fully understand the pathogenetic mechanisms leading to the onset of the disorder More studies investigating the impact of epigenetic modifications on the levels and the structure of FVIII and on the development of autoantibodies towards FVIII, leading to the clinical onset of AHA, are needed to understand this complex disease. Here, F8 is linked to autoimmune hemolytic anemia.