The GTH-AH 01/2010 study presented that autoantibodies in patients with AHA are not only specific for FVIII but for other immune targets (ANA WITH human epithelial cell (HEp-2) immunofluorescence, AF nuclear, and cytoplasmic) (78% produced antibodies for any other target than FVIII compared with 46% of controls, OR 4.16, 1.98–8.39) [50]. The gene discussed is F8; the disease is autoimmune hemolytic anemia.